The effect of limbic and extralimbic electrical stimulations upon prolactin secretion in humans |
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| Authors: | Michael R. Sperling Charles L. Wilson |
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| Affiliation: | 1. Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand;2. Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand;3. Department of Obstetrics and Gynecology, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand;4. Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand;5. Center of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok, Thailand;1. IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia, Avda. Blasco Ibañez, 21, 46010, Valencia, Spain;2. International University of Valencia, C/Pintor Sorolla, 21, 46002, Valencia, Spain;1. Department of Neurology, Oslo University Hospital, Oslo, Norway;2. Department of Neurology, Østfold County Hospital, Fredrikstad, Norway;3. University of Oslo, Oslo, Norway;1. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia;3. NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;5. Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | The effect that extra-hypothalamic regions of the brain have upon prolactin secretion in humans was evaluated by performing electrical stimulations. Thirty-nine stimulations were performed, 22 to basolateral amygdala, 12 to hippocampus and 5 to orbitofrontal, supplementary motor and cingulate cortex. Only two stimulations causing high-frequency widespread limbic afterdischarges were followed by significant prolactin elevation. Four low-frequency afterdischarges involving amygdala and anterior hippocampus, one amygdala stimulus-dependent discharge and 19 amygdala, 8 hippocampal and 5 frontal sub-afterdischarge threshold stimulations had no prolactin elevation. These results fail to replicate earlier studies. We suggest that there is no evidence that the amygdala regulates serum prolactin within physiologic ranges, but that the regulation of prolactin may depend primarily upon other sub-cortical structures. |
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| Keywords: | prolactin amygdala hippocampus afterdischarge |
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