Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease. |
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Authors: | Jan Herzog Jens Volkmann Paul Krack Florian Kopper Monika P?tter Delia Lorenz Meike Steinbach Stefan Klebe Wolfgang Hamel Bettina Schrader Dieter Weinert Dieter Müller Hubertus M Mehdorn Günther Deuschl |
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Institution: | Department of Neurology, Christian-Albrechts Universit?t Kiel, Kiel, Germany. |
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Abstract: | We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary. |
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Keywords: | deep brain stimulation subthalamic nucleus |
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