Changes in CMDP and DPOAE during acute increased inner ear pressure in the guinea pig |
| |
Authors: | W L Valk H P Wit F W J Albers |
| |
Institution: | (1) Department of Otorhinolaryngology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands |
| |
Abstract: | During and after an increase of inner ear pressure, induced by injection of artificial perilymph, the 2f
1 − f
2 and f
2 − f
1 distortion products (DPs) in cochlear microphonics (CM) and otoacoustic emissions (OAE) were recorded in the guinea pig.
An inner pressure increase of ∼600 Pa gave only small changes in CMDP and DPOAE. Along with a decrease in f
1 amplitude, a small decrease in amplitude of the 2f
1 − f
2 and a small increase in the f
2 − f
1 were measured in CM. This matches a shift from a symmetrical position of the operating point for hair cell transduction,
leading to an increase in even-order distortion and a decrease in odd-order distortion. Similar, a decrease in 2f
1 − f
2 DPOAE was expected. This might be the case at the generation sites but this effect was then more than compensated for by
a better middle ear transfer, accounting for the increase of 0.4 dB of the 2f
1 − f
2 DPOAE amplitude. In conclusion, changes of overall inner ear fluid pressure have minor effects on cochlear function. This
is a relevant finding for further understanding of diseases with changed inner ear fluid volumes, as Ménière’s. |
| |
Keywords: | Perilymph Injection Inner ear pressure 2f 1 − f 2 f 2 − f 1 CMDP DPOAE Guinea pig |
本文献已被 SpringerLink 等数据库收录! |
|