| 胰岛素样生长因子1及受体与肿瘤的关系 |
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| 引用本文： | 戴晓晓,陈同钰. 胰岛素样生长因子1及受体与肿瘤的关系[J]. 医学综述, 2006, 12(23): 1450-1452 |
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| 作者姓名： | 戴晓晓 陈同钰 |
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| 作者单位： | 常州市第一人民医院病理科,江苏,常州,213003 |
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| 摘 要： | 胰岛素样生长因子1(IGF-1)及其受体(IGF-1R)是体内重要的生长因子。资料表明IGF-1R介导IGF-1的活性,促进细胞增殖、转化、抑制细胞凋亡与肿瘤的发生、发展关系密切。而肿瘤细胞的凋亡、浸润、转移的生物学特性则是由相关因子作用表现的,如Bcl-2家族、整合素、血管内皮生长因子等。本文就IGF-1和IGF-1R与这些因子的作用机制作一阐述。
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| 关 键 词： | 胰岛素样生长因子1 胰岛素样生长因子1受体 肿瘤 |
| 文章编号： | 1006-2084（2006）23-1450-03 |
| 收稿时间： | 2006-02-29 |
| 修稿时间： | 2006-10-25 |
The Relationship of Insulin-like Growth Factor 1 and its Receptor with Tumor |
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| DAI Xiao-xiao,CHEN Tong-yu. The Relationship of Insulin-like Growth Factor 1 and its Receptor with Tumor[J]. Medical Recapitulate, 2006, 12(23): 1450-1452 |
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| Authors: | DAI Xiao-xiao CHEN Tong-yu |
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| Abstract: | Insulin-like growth factor 1 and its receptor are important growth factors in body.Researches have indicated that The IGF-1 receptor can promote cell proliferation and transformation and inhibit cells apoptosis which is closely related to the genesis and development of tumor by mediating the activity of IGF-1,The tumor bionomics including its apoptosis,infiltration and metastasis is the manifestation of related factors such as Bcl-2、integrin、VEGF and so on.In this review we discussed the mechanisms of action between IGF-1 and its receptor(IGF-1R) and these factors. |
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| Keywords: | Insulin-like growth factor 1 Insulin-like growth factor 1 receptor Tumor |
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