Acute Increase in Hepatic Arterial Flow During TIPS Identified by Intravascular Flow Measurements |
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Authors: | Boris Radeleff Christof-Matthias Sommer Tobias Heye Ruben Lopez-Benitez Peter Sauer Jan Schmidt Haus-Ulrich Kauczor Goetz Martin Richter |
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Institution: | (1) Department of Diagnostic Radiology, University of Heidelberg Medical Center, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany;(2) Department of Internal Medicine IV, Gastroenterology, Hepatology, Infectious Diseases, and Intoxications, University of Heidelberg Medical Center, Heidelberg, Germany;(3) General, Visceral, and Accident Surgery, University of Heidelberg Medical Center, Heidelberg, Germany |
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Abstract: | The purpose of this study was to investigate alterations of hepatic arterial flow during transjugular intrahepatic portosystemic
stent shunt (TIPS) applying intravascular Doppler sonography. This prospective monocenter study included 25 patients with
liver cirrhosis (alcohol induced n = 19], chronic hepatitis associated n = 3], primary biliary cirrhosis associated n = 1], and cryptogenic n = 2]) successfully treated with TIPS. All patients underwent intravascular hepatic arterial flow measurements during TIPS
using an endoluminal flow sensor. The average arterial peak velocity (APV) and the maximum arterial peak velocity (MPV) were
registered. Twenty-two patients (88%) showed increased APV, one patient (4%) showed unaffected APV, and two patients (8%)
showed decreased APV after TIPS. The average portosystemic pressure gradient decreased significantly, from 22.0 ± 5.1 mmHg
before TIPS to 11.0 ± 4.1 mmHg after TIPS (−50.0%; p < 0.0001). The average APV increased significantly, from 41.9 ± 17.8 cm/s before TIPS to 60.7 ± 19.0 cm/s after TIPS (+44.9%; p < 0.0001). The average MPV increased significantly, from 90.8 ± 31.7 cm/s before TIPS to 112.6 ± 34.9 cm/s after TIPS (+24.0%; p = 0.0002). These changes in perfusion set in within seconds after TIPS tract formation in all the patients with increased
APV. We conclude that TIPS-induced portosystemic decompression leads to a significant increase in hepatic arterial flow. The
changes occurred within seconds, suggesting a reflex-like mechanism. |
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Keywords: | Transjugular intrahepatic portosystemic stent shunt Hepatic artery Portal vein Hepatic perfusion Intravascular flow measurements |
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