Pancreatic islet allograft prevents basement membrane thickening in the diabetic rat retina |
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| Authors: | A A F Sima S Chakrabarti W J Tze J Tai |
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| Institution: | (1) Neuropathology Research Laboratories, Department of Pathology, University of Manitoba, Winnipeg, Manitoba;(2) Department of Endocrinology, University of British Columbia, Vancouver, British Columbia, Canada |
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| Abstract: | Summary Progressive basement membrane thickening is a characteristic structural abnormality in diabetic tissues in cluding the retina. We examined the effect of pancreatic islet allotransplantation on basement membrane thickening and irregularities in retinal capillaries of the streptozotocin-diabetic rat. Diabetic animals received intraportal or intracerebral pancreatic islet allografts. Animals with functioning allografts demonstrated euglycaemia and a normal body weight gain during the 400-day post-transplantation period. The characteristic thickening of capillary basement membranes was completely prevented in animals with successful transplantation. The present findings suggest that islet allotransplantation may be a rational therapeutic approach in the treatment of diabetes mellitus and the prevention of ensuing secondary complications. |
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| Keywords: | Islet cell transplantation streptozotocin-diabetic rats basement membrane retina |
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