多种耐药基因蛋白在初治乳腺癌中的表达

目的:观察乳腺癌多种常见耐药相关基因蛋白的表达情况,探讨乳腺癌原发性耐药的状态及可能机制。方法:选取术前未行化疗及内分泌治疗的369例乳腺癌标本,采用免疫组化法检测LRP、GST、P190及P170的表达情况,观察上述指标之间以及与肿瘤大小、淋巴结转移的相关性。结果:这些基因蛋白表达的阳性率分别为:LRP57.99%,GST32.79%、P1905.96%和P17038.12%;多基因共表达率为40.10%;LRP与P170之间呈正相关(r=0.1702,P<0.001);4种耐药相关基因蛋白表达与肿瘤大小及淋巴结转移之间均无相关性(P>0.05)。结论:初治乳腺癌中存在多个耐药相关基因蛋白表达及共表达,可能反映了乳腺癌的原发性耐药状态及其复杂的机制。

Expressions of several different type of drug resistance associated proteins in initially treated breast cancer

Objective:To explore the status and mechanism of primary drug resisuance of breast cancer by observing expressions of multiple drug resistance associated proteins. Methods:Data from 369 breast cancer without preoperative chemotherapy and endocrine therapy, expressions of LRP, GST, P190, P170 were measured by immunohistochemistry and evaluated the correlations with tumor size and lymphnode status.Results:The positive rate was LRP 57.99%, GST 32.79%, P190 5.96%, P170 38.12% respectively; The rate of multiple genes coexpression was 40.10%; Correlation coefficient of LRP and P170 was 0.170 2(P<0.001). There was no correlation of the four proteins with tumor size or lymphnode status (P>0.05).Conclusion:There are expressions and coexpressions of several different type of drug resistance associated proteins in initially treated breast cancer, which reflect the status and complicated mechanism of primary drug resistance.