妊娠期糖尿病高危因素与产后早发糖代谢异常的关系

【目的】探讨妊娠期糖尿病(GDM)传统高危因素与妊娠结局及产后早发糖代谢异常的关系&#65377;【方法】 3 017名孕妇以高危因素或50 g葡萄糖筛查试验进行GDM筛查,阳性者行75 g 口服葡萄糖耐量试验(OGTT)确诊GDM,GDM孕妇分为高危因素组(G1组, n = 143)与非高危因素组(G2组,n = 175),并于产后6 ~ 8周及产后6 ~ 12月复查OGTT&#65377; 【结果】 3 017名孕妇中318例确诊GDM,存在高因危素的孕妇GDM患病率明显高于无高危因素的孕妇(41.81% VS 6.54%, P < 0.01),且分娩期并发症发生率&#65380;早产率以及胎儿体质量更高,产后6 ~ 12个月持续糖代谢异常率亦明显升高&#65377;Logistic回归分析显示糖尿病家族史&#65380;尿糖阳性与产后糖代谢异常相关&#65377; 【结论】 存在GDM高危因素的孕妇GDM患病率明显升高,产后持续糖代谢异常的概率亦显著升高,其中尿糖阳性与糖尿病家族史有较高的相关性&#65377;

Relationship between Risk Factors of GDM and Postpartum Early Abnormal Glucose Regulation

【Objective】 To investigate the relationship between traditional risk factors of gestational diabetes mellitus (GDM) and pregnancy outcome as well as postpartum early abnormal glucose regulation. 【Methods】 Risk factors or 50 g oral glucose tolerance test (OGTT) were used to scan GDM in 3017 pregnant women, the 75 g OGTT were performed to confirm the diagnosis of GDM in those with positive results. GDM women were divided into two groups: women with risk factors (n = 143) and without risk factors (n = 175). All GDM women were recruited to take 75 g OGTT at 6-8 weeks and 6-12 months after delivery. 【Results】 Total 318 GDM were confirmed in those 3017 pregnant women. The prevalence of GDM in women with risk factors were higher than those without risk factors (41.81% vs 6.54%, P < 0.01). Additionally, compare to those without risk factors, women with risk factors has higher pregnant complications, higher premature birth rate, and birth-weight. Also a higher incidence of early postpartum abnormal glucose tolerance was observed in those with GDM risk factors. Logistic regression analysis indicated that family history of diabetes and positive uric glucose were relative to the early postpartum abnormal glucose tolerance. 【Conclusions】 The GDM risk factors are not only the predictor of GDM, but also are relative to postpartum early abnormal glucose regulation. Among these risk factors, family history of diabetes and positive uric glucose are of greater contribution.