AnnexinⅡ与肿瘤的研究进展

AnnexinⅡ是一种钙依赖性磷脂结合蛋白,有一个短的决定其生物学特性的疏水N-端结构域和一个参与磷脂结合的核心区。AnnexinⅡ参与了多种生物学活动,包括信号转导、细胞迁移、DNA合成、细胞增殖和凋亡等。近来多项研究表明,AnnexinⅡ在多种肿瘤中表达失调,且其表达水平和肿瘤的发生、浸润、转移、临床分期和愈后密切相关。仅就AnnexinⅡ的生物学特点及其与肿瘤的关系研究进行综述。

Study Progress of AnnexinⅡ and Tumor

AnnexinⅡ is a calcium-dependent,phospholipid-binding protein found on many cell types.It consists of a short hydrophobic tail,which dictates its function,and a core domain,which is involved in phospholipid binding.AnnexinⅡ has been implicated in a number of biochemical processes,including signal transduction,cellular motility,DNA synthesis,cell proliferation and apoptosis.Recently,AnnexinⅡ has been shown to be dysregulated in many neoplastic diseases,the expression levels of which is associated closely with the genesis,infiltration,metastasis,clinical stage and prognosis of tumor.This article reviews AnnexinⅡ of its biological characters and relationship with tumor.