妊娠期肝细胞癌的临床特征

目的 探讨妊娠期肝细胞癌(hepatocellular carcinoma,HCC)的临床特征.方法 回顾性分析4例妊娠期HCC病人的临床资料.结果 4例病人乙肝表面抗原均为阳性,3例血清甲胎蛋白水平明显增高(310.1～5630.0 ng/m1).3例病人在诊断时HCC已为晚期,分别于诊断后第7个月、第6个月、第4个月病死.1例早期HCC行根治性切除后已无瘤生存26个月.结论 妊娠期HCC就诊时多为疾病晚期预后差.建议对妊娠期妇女特别是乙肝流行区域的乙肝携带者行甲胎蛋白和肝脏超声筛查,以早期发现HCC,提高生存期.

Clinical features of hepatocellular carcinoma during pregnancy

Objective To explore the clinical features of hepatocellular carcinoma (HCC) during pregnancy. Methods Clinical data of 4 patients with HCC in pregnancy were retrospectively analyzed.Results All 4 patients were positive for hepatitis B surface antigen. A marked increase in maternal serum a-fetoprotein (AFP) was found in 3 patients (310.1-5630.0 ng/ml ). Three patients were diagnosed at their advanced stages and died of disease in the 4th, 6th and 7th months, respectively. One patient diagnosed as having early HCC underwent curative surgery and has been without recurrence for 26 months. Conclusion The overall survival of patients with HCC in pregnancy is grim because most patients are diagnosed in the advanced stage. Surveillance with AFP and ultrasonography should be recommended for pregnant woman for the detection of early HCC, especially in hepatitis B virus carriers from high endemic areas, to improve patient survival.