Ca2+ transport of the skeletal muscle sarcoplasmic reticulum during readaptation of rats after a 40-day load relief on the hind paws |
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| Authors: | V V Stepanova I A Popova Yu V Arkhipenko |
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| Institution: | (1) Institute of Biomedical Problems, Ministry of Health, Moscow;(2) Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | The rate of Ca2+ accumulation in the sarcoplasmic reticulum of the skeletal muscle (m. gastrocnemius lateralis, m. vastus medialis, andm. soleus) is studied in rats under conditions of functional off-loading of the hind paws (suspending animals by the tail). The rate
of Ca2+ transport in the sarcoplasmic reticulum is shown to be stepped up in all these muscles. In the sarcoplasmic reticulum ofm. gastrocnemius lateralis andm. vastus medialis the Ca2+ transport rate reliably drops, which does not occur inm. soleus. During a 2-week period of readaptation of animals suspended for 40 days, the Ca2+-transporting function of them. soleus sarcoplasmic reticulum gradually recovers to reach the control values, whereas the time course of recovery of Ca2+-pump activity in the sarcoplasmic reticulum ofm. gastrocnemius lateralis andm. vastus medialis has a phasic pattern.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsity, Vol. 118, N
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12, pp. 591–595, December, 1994
Presented by A. I. Grigor'ev, Member of the Russian Academy of Medical Sciences |
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| Keywords: | Ca 2+ transport sarcoplasmic reticulum hypokinesia hypodynamia |
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