乳腺癌的复发、转移与c-erbB-2、BCSG1等多指标相关性研究

 目的：探讨人表皮生长因子受体（c-erbB-2）、乳腺癌特异基因(BCSG1)等多指标在乳腺癌中的表达及其对复发、转移的影响以及其间的相关性。方法：采用免疫组化SP法检测随机抽取的随访5年临床病理资料完整的58例浸润性乳腺癌组织中的c-erbB-2、BCSG1以及雌激素受体（ER）、孕激素受体（PR）、微血管计数（MVD）、血管内皮生长因子（VEGF）、淋巴管内皮生长因子（VEGF-C）、淋巴管内皮生长因子受体（FLT-4）、淋巴管计数（LVD）蛋白的表达情况，结合临床、病理形态学资料分析多项指标对复发、转移的影响。结果：c-erbB-2、BCSG1、VEGF-C、LVD蛋白在乳腺癌组织中的阳性表达率分别为25.9%、62.1%、36.2%、32.8%；4指标表达在伴淋巴结转移组明显高于无转移组（P<0.05）；在复发、转移组其表达率同样显著高于无复发、转移组（P<0.05），且MVD在复发、转移组也增高（P<0.05）。结论：c-erbB-2、BCSG1、VEGF-C、LVD蛋白与患者的复发、转移密切相关，乳腺癌c-erbB-2、BCSG1蛋白在乳腺癌中的表达呈正相关，其中，BCSG1蛋白表达的灵敏性高，可尝试作为预测乳腺癌预后的指标。

Relationship between c-erbB-2, BCSG1 expression and recurrence, metastasis in breast cancer

AIM:To assess the significance of c-erbB-2,BCSG1(breast cancer specific gene-1)expression and other parameters in recurrence or metastasis of breast cancer.METHODS:The expression of c-erbB-2,BCSG1,and ER,PR,MVD,VEGF,VEGF-C,FLT-4,LVD were determined with the SP immunohistochemical method in 58 cases of invasive breast cancer patients occurred over 5 years.The cases were used to analyze the effect of c-erbB-2,BCSG1,VEGF-C and ER,PR,MVD,VEGF,FLT-4,LVD expression on clinical-pathological manifestations and prognosis in breast cancer.RESULTS:The expression rates of c-erbB-2,BCSG1,VEGF-C,LVD were respectively 25.9%,62.1%,36.2%,32.8% in association with the lymph node metastasis and recurrence of breast cancer(P<0.05),the expression rate of MVD was also increased significantly(P<0.05).CONCLUSION:The c-erbB-2,BCSG1,VEGF-C,LVD are highly expressed and strongly correlated with the lymph node metastasis and recurrence of breast cancer,of which BCSG1 may be used as a predictor of prognosis.