hMSH2、PCNA及P53在子宫颈癌组织中的表达及意义

目的]探讨子宫颈癌hMSH2、PCNA及P53蛋白表达的状况和意义。方法]用免疫组织化学SP法检测54例子宫颈癌的hMSH2、PCNA及P53蛋白表达。结果]子宫颈癌组织hMSH2、PCNA及P53蛋白表达阳性率为62.96%(34/54)、75.93%(41/54)及66.67%(36/54);在hMSH2阳性表达和阴性表达的子宫颈癌病例PCNA阳性表达率为85.29%(29/34)和60.00%(12/20),P53阳性表达率为76.47%(26/34)和50.00%(10/20)。hMSH2与PCNA、hMSH2与P53表达呈正相关(P<0.05)。结论]hMSH2可能通过与PCNA、P53蛋白相互作用参与子宫颈癌的发生。

Expressions of hMSH2,PCNA and P53 in cervical cancers and its significance

Objective] To analyze the relationship of hMSH2、PCNA and P53 protein expression in cervical cancers and its significance.Methods] Immunohistochemistry was used to examine the proteins expression of hMSH2、PCNA and P53 in 54 cases of cervical cancers.Results] In cervical cancer,the positive expression rates of hMSH2,PCNA and P53 protein were 62.96%(34/54),75.93%(41/54)and 66.67%(36/54).In the cervical cancer cases with and without hMSH2 expression,the positive expression rates of PCNA were 85.29% and 60.00%;the rates of P53 were 76.47% and 50.00%.hMSH2 and PCNA/hMSH2 and P53 protein expression were positively correlated(P<0.05).Conclusions] Interaction of hMSH2 to PCNA and P53 may be the carcinogenesis of cervical cancer.