临沂市健康人群白喉和破伤风抗体水平调查

目的 为有计划地进行人群抗体水平监测,了解人群免疫状况,为制定免疫对策、评价免疫效果提供依据。方法 采用分层随机抽样的方法,2001、2003、2004年调查了临沂市10个县（区）0-39岁847人的白喉和破伤风抗体水平。结果 白喉和破伤风抗体总阳性率分别为77.80%和74.03%,阳性率均是0-4岁组最高,20-39岁组最低;山区县低于平原县和市区。白喉和破伤风抗体几何平均浓度分别为0.0997U/ml和0.0674U/ml,均是8-10岁组最高,20-39岁组最低。结论 临沂市白喉和破伤风疫苗基础免疫的效果可靠,但随着年龄的增长,免疫力衰退而重新成为易感者,故应及时对成人加强百日咳、白喉的免疫,并在新生儿破伤风高危县区对育龄期妇女开展破伤风疫苗免疫。

Survey of the diphtheria and tetanus antibody level among the healthy population in Linyi City

Objective To conduct antibody surveillance and understand the immumzallon status among the population, develop immunization strategies and provide evidence for evaluating immunization effect. Methods We investigated the diphtheria and tetanus antibody level of 847 persons aged 0 - 39 years old in 10 counties of Linyi City during 2001 -2004, multilevel cluster random sampling method was used in the study. Results The overall positive rates of diphtheria and tetanus antibody were 77.80% and 74.03% respectively, for both of them, the highest positive rate was among the children aged 0 - 4 years old, the lowest one was among the a- dults aged 20 -39 years old, and the rate among the population living in mountain areas was lower than that among the population living in plain and urban areas. The GMC of diphtheria and tetanus antibody were 0. 0997 IU/ml and 0.0674 IU/ml respectively, for both of them, the highest GMC was among the children aged 8 -10 years old, the lowest one was among the adults aged 20 -39 years old. Conclusion The results suggested that the effect of routine immunization Of diphtheria and tetanus toxoid was reliable, but the immunity faded with age increasing then vaccinated persons became new susceptible persons. It is necessary to strengthen the vaccination of diphtheria toxoid to adults in time, and conduct the tetanus toxoid immunization to the child - bearing age women in the counties of tetanus high - risk for neonate.