Beam collimation and bolusing material optimizations for 10boron neutron capture enhancement of fast neutron (BNCEFN): definition of the optimum irradiation technique |
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| Authors: | Pignol J P Paquis P Cuendet P Gibon D Diop C M Sabattier R |
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| Affiliation: | 1. Service de Radiothérapie, Hôpital du Hasenrain, Mulhouse, Cedex, France;2. Service de Neurochirurgie, Hôpital Pasteur, Nice, Cedex, France;3. Commissariat à L’Energie Atomique, Direction des Réacteurs Nucléaires Yvette, Cedex, France;4. Service de Radiothérapie, Centre Oscar-Lambret, Lille, France;1. Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia;2. Department of Physics, Faculty of Science, Isra University, Amman 11622, Jordan;3. Department of Science and Technology, Philippine Nuclear Research Institute (DOST-PNRI), Commonwealth Avenue, Diliman, Quezon City 1101, Philippines;4. University College, Benra, Dhuri, Punjab 148024, India;5. Department of Physics, Punjabi University, Patiala, Punjab 147002, India;6. Physics Department, Faculty of Science, University of Tabuk, Tabuk 47512, Saudi Arabia;7. Institute of Laser, Sudan University of Science and Technology, Sudan;8. Department of Physics, Chittagong University of Engineering and Technology, Chattogram, Bangladesh;1. Department of Nuclear Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia;2. Department of physics, Faculty of Science, Isra University, Amman, Jordan;3. Department of physics, college of science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia;4. University College Benra, Dhuri, Punjab 148024, India;5. Department of Physics, Punjabi University, Patiala, Punjab 147002, India;6. Department of Science and Technology – Philippine Nuclear Research Institute (DOST-PNRI), Commonwealth Avenue, Diliman, Quezon City 1101, Philippines;7. Department of Physics, Suleyman Demirel University, Isparta,Turkey;1. Department of Physics, Faculty of Science, Isra University, Amman, Jordan;2. Department of Nuclear Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia;3. University College, Benra-Dhuri, Punjab 148024, India;4. Department of Physics, Punjabi University, Patiala, Punjab 147002, India;5. Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia;6. Department of Science and Technology – Philippine Nuclear Research Institute (DOST-PNRI), Commonwealth Avenue, Diliman, Quezon City 1101, The Philippines;7. Afyon Kocatepe University, Faculty of Engineering, Department of Materials Science and Engineering, Afyonkarahisar, Turkey;1. Departamento de Ingeniería Energética, ETSI Industriales, Universidad Politécnica de Madrid, José Gutiérrez Abascal 2, 28006, Madrid, Spain;2. Biología y Técnica de la Radiación, S.L. (Bioterra, S.L.), C. Camino de los Perdigones 2, 28224, Pozuelo de Alarcón, Madrid, Spain;3. Unidad Académica de Estudios Nucleares, Universidad Autónoma de Zacatecas, C.Cipres 10, Zacatecas, 98060, Mexico;1. Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia;2. University College Benra, Dhuri, Punjab, 148024, India;3. Department of Physics, Punjabi University, Patiala, Punjab 147002, India;4. Department of Science and Technology – Philippine Nuclear Research Institute (DOST-PNRI), Commonwealth Avenue, Diliman, Quezon City, 1101, Philippines;5. SSPA “Scientific-Practical Materials Research Centre of NAS of Belarus”, 220072, Minsk, Belarus;6. Laboratory of Single Crystal Growth, South Ural State University, 454080, Chelyabinsk, Russia;7. Department of Physics, Faculty of Science, Isra University, Amman, Jordan;8. Department of Nuclear Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University (IAU), Dammam, Saudi Arabia |
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| Abstract: | Purpose: In boron-10 neutron capture enhancement of fast neutron irradiation (BNCEFN), the dose enhancement is correlated to the 10B concentration and thermal neutron flux. A new irradiation technique is presented to optimize the thermal neutron flux.Methods and Materials: The coupled FLUKA and MCNP-4A Monte Carlo codes were used to simulate the neutron production and transport for the Nice and Orleans facilities.Results: The new irradiation technique consists of a 20-cm lead blocks additional collimator, placed close to the patient’s head, which is embedded in a pure graphite cube. A 24-fold thermal neutron flux increase is calculated between a 5 × 5 cm2 primary collimated field, with the patient’s head in the air, and the same field size irradiated with the optimum irradiation technique. This increase is more important for the p(60)+Be Nice beam than for the p(34)+Be Orleans one. The thermal neutron flux is 2.1 × 1010 nth/Gy for each facility. Assuming a 100 μg/g 10B concentration, a physical dose enhancement of 22% is calculated. Moreover, the thermal neutron flux becomes independent of the field size and the phantom head size.Conclusion: This technique allows conformal irradiation of the tumor bed, while the thermal neutron flux is enhanced, and spreads far around the tumor. |
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