内毒素对大鼠牙髓组织形成修复性牙本质的影响

目的：探讨局部内毒素刺激对大鼠牙髓形成修复性牙本质的影响。方法：以内毒素注射于火鼠牙阍组织,内f蟮豢试剂盒检测血液中及逆行进入牙髓组织中的内毒素浓度,HE染色观察修复性牙本质形成情况。结果：血液中实验组勺埘照纰间内毒素的含量差别有统计学意义,P〈0．001。牙髓中实验组与阴性对照组,以及与窄白对照组问内毒素的含量麓川仃统计学意义,P〈O．001。HE染色可见注射位点附近修复性牙本质形成明显,髓腔变窄,牙本质小管排列紊乱。结论：内薄素仡一定条件下能刺激夫鼠牙髓组织,使其发生保护性反应,从而促进其矿化作用,加速修复性牙本质形成。

Effect of lipopolysaccharide on the production of reparative dentin in rat dental pulp tissue.

Objective：Tu investigate the Effect of lipopolysaccharide on the production of reparative dentin in rat dental pulp tissue. Method： Rat periudontium was injected by Escherichia culi （Ee） lipopolysaccharide,and the concentra- lion of I,PS in blood and rat dental pulp tissue was detected by ehromogenie end-point tachypleus amebocyte lysate （CE TAI,） .The production of reparative dentin was observed by HE staining. Result：The concentration of LPS of the experimen- tal group was significantly higher than the concentration of control group in blood,P 〈0.0001：The coneentration of LPS of the experimental group was significantly higher than both negative control group and blank control group in dental pulp tis- sue, P 〈0.0001.HE staining showed that reparative dentin was produced nearby the injection site, where the dentinal tubule arrangment turned out to be rather disordered. Conclusion：The results indicate that LPS can stimulate dental pulp tissue to bring abut, t reactions of immune defense and promote the production of reparative dentin in certain situation.