静脉注射丙种球蛋白治疗川崎病的疗效观察

目的观察静脉注射丙种球蛋白治疗川崎病的临床效果。方法选取我院2008年3月至2012年8月收治的162例川崎病患儿,随机分为2组。对照组79例,采用常规治疗方法;观察组83例,在对照组治疗的基础上加用丙种球蛋白注射液,观察两组的临床治疗效果。结果观察组的平均住院时间、总热程、退热时间明显短于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组的CRP和ESR均低于对照组,且差异有统计学意义(P<0.05)。两组不良反应的发生率差异无统计学意义(P>0.05)。结论早期大剂量静脉注射丙种球蛋白治疗川崎病,其疗效确切且安全可靠。

Efficacy of intravenous gamma globulin on Kawasaki disease

Objective To observe the clinical effect of intravenous gamma globulin on Kawasaki disease. Methods 162 patients with Kawasaki disease in our hospital for March 2008 to Angust 2012 were divided into 2 groups randomly,patients in control group(n=79)were treated with conventional treatment,and patients in observation group(n=83) were treated with gamma globulin injection and conventional therapy,clinical efficacy of the two groups were observed. Results The average hospitalization duration,the total duration of fever and fever clearance time in observation group were significantly shorter than those in control group(P<0.05).After treatment,CRP and ESR of observation group were lower than those of control group(P<0.05).No significant difference in the incidence of adverse reactions was observed between the two groups(P>0.05). Conclusion Early high-dose intravenous gamma globulin treatment for Kawasaki disease is safe and reliable.