国产混合重组人胰岛素30／70注射液联合二甲双胍治疗初发2型糖尿病疗效观察

目的观察国产混合重组人胰岛素30／70注射液联合二甲双胍治疗初发2型糖尿病（T2DM）的临床疗效。方法将72例初发T2DM患者随机分为治疗组和对照组各36例。对照组采用国产混合重组人胰岛素30／70注射液治疗，治疗组在对照组基础上予二甲双胍口服治疗。观察2组治疗前后体质量、体质量指数（BMI）、腰臀比（WHR）、空腹胰岛素（FINS）、空腹血糖（FPG）、餐后2h血糖（2hPG）、糖代血红蛋白（HbA1c）及三酰甘油（TG）、总胆固醇（TC）、低密度酯蛋白胆固醇（LDL—C）水平和胰岛素抵抗指数（HOMA—IR）。结果治疗后，治疗组各指标均低于治疗前；对照组FPG、HbA1c、TG、TC、LDL-C、HOMA-IR低于治疗前，差异均有统计学意义（P〈0．05）；治疗后，治疗组FPG、HbA1c及HOMA-IR均低于对照组，差异均有统计学意义（P〈0．05）。结论国产混合重组人胰岛素30／70注射液联合二甲双胍治疗T2DM，疗效较满意，值得基层医院推广应用。

Effect observation of domestic hybrid recombinant human insulin 30/70 injection combined with metformin in the treatment of newly diagnosed type 2 diabetic mellitus

Objective To observe the efficacy of domestic hybrid recombinant human insulin 30/70 injection combined with metformin in the treatment of newly diagnosed type 2 diabetic mellitus （T2DM）. Methods 72 cases patients with newly diagnosed T2DM were randomly divided into treatment group and control group, each of 36 cases. Control group were treated with domestic hybrid recombinant human insulin 30/70 injection, treatment group, based on control group, were terated with oral metformin. Observed the level of body weight, body mass index （ BMI）, waist-hip ratio （ WHR）, fasting insulin （FINS） ,fasting plasma glucose （FPG）, 2h postprandial blood glucose （2hPG）, sugar-generation hemoglobin （HbA1 c） and three triglyceride （TG）, total cholesterol （TC） , low density lipoprotein cholesterol （LDL-C） and insulin resistance index （HOMA-IR） of 2 groups before and after treatment. Results After treatment, all indicators of treatment group were lower than before treatment ; FPG, HbA1 c,TG, TC, LDL-C, HOMA-IR of control group were lower than before treatment, the differences were statistically significant （ P 〈 0.05 ） ; After treatment, the level of FPG, HbA1 c and HOMA-IR of treatment group were low- er than that of control group,the difference was statistically significant （P 〈 0. 05）. Conclusion The effect of domestic hybrid recombinant human insulin 30/70 injection combined with metformin in the treatment of newly diagnosed type 2 diabetic mellitus is satisfactory,worthy of primary hospitals＇ application.