多体素~1H-MRS对星形细胞肿瘤边界诊断的研究 |
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引用本文: | 徐容,缪飞,吴志远,倪根雄,尚寒冰,赵卫国,. 多体素~1H-MRS对星形细胞肿瘤边界诊断的研究[J]. 放射学实践, 2010, 25(4): 376-380 |
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作者姓名: | 徐容 缪飞 吴志远 倪根雄 尚寒冰 赵卫国 |
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作者单位: | 上海交通大学医学院附属瑞金医院放射科,上海,200025 |
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基金项目: | 上海市科学技术委员会科研计划项目,上海市重点学科建设项目资助 |
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摘 要: | 目的:探讨多体素^1H-MRS在星形细胞瘤边界诊断中的临床应用价值。方法:对20例经病理证实的星形胶质细胞瘤患者行多体素^1H-MRS检查,采集NAA、Cho、Cr等波峰,计算并比较肿瘤不同区域多种代谢物比值。结果:多体素^1H-MRS示肿瘤区、近侧瘤周区NAA/Cho、NAA/Cr和Cho/Cr平均值与参照区比较差异均有显著性意义(P〈0.05);高、低级星形细胞瘤间,多组代谢物比值差异具有统计学意义(P〈0.05)。结论:MRS示Ⅲ~Ⅳ级星形细胞瘤在肿瘤区边缘2cm范围代谢物比值仍和参照区差异有显著统计学意义,提示存在肿瘤浸润,Ⅰ~Ⅱ级星形细胞瘤在肿瘤区边缘1cm范围代谢物比值仍和参照区差异有显著统计学意义,提示存在肿瘤浸润。
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关 键 词: | 星形细胞瘤 磁共振成像 磁共振波谱学 |
Value of multivoxel 1H-MRS in evaluating the border of astrocytoma |
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Affiliation: | XU Rong,MIAO Fei,WU Zhi-yuan,et al.(Department of Radiology,Ruijin Hospital,Medical College of Shanghai Jiaotong University,Shanghai 200025,P.R.China ) |
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Abstract: | Objective:To investgate the value of multivoxel ^1H-MRS in evaluating the border of astrocytoma.Methods:20 cases of astrocytoma were all examined by routine MR scan and ^1H-MRS.Spectra of different areas were taken and fitted areas in the spectrum for NAA,Cho,Cr and other metabolite peaks were measured and calculated for each voxel.Results:In multivoxel ^1H-MRS from enhanced and perienhancement areas of the lesion,the ratios of NAA/Cho,NAA/Cr and Cho/Cr changed significantly when compared with those of normal brain tissues (P〈0.05).Between high and low grade astrocytic tumors,the mean values of different metabolite peak ratios revealed strong correlations.Conclusion:Multivoxel ^1H-MRS is useful in defining the border of tumors and making the histological classification of astrocytoma. |
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Keywords: | Astrocytoma Magnetic resonance imaging Magnetic resonance spectroscopy |
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