Quartromicin, a complex of novel antiviral antibiotics. I. Production, isolation, physico-chemical properties and antiviral activity. |
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| Authors: | M Tsunakawa O Tenmyo K Tomita N Naruse C Kotake T Miyaki M Konishi T Oki |
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| Affiliation: | Bristol-Myers Squibb Research Institute, Tokyo, Japan. |
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| Abstract: | A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus. |
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