| 大黄藿苓汤对腺嘌呤致大鼠慢性肾衰PDGF、bFGF表达的影响 |
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| 引用本文： | 杨幼新,韩顺平,韩优星,苑朝升,杨曼. 大黄藿苓汤对腺嘌呤致大鼠慢性肾衰PDGF、bFGF表达的影响[J]. 四川中医, 2007, 25(2): 26-28 |
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| 作者姓名： | 杨幼新 韩顺平 韩优星 苑朝升 杨曼 |
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| 作者单位： | 天津中医药大学,天津,300193;解放军272医院,天津,300020 |
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| 摘 要： | 目的:探讨大黄藿苓汤对慢性肾衰大鼠肾脏的保护作用及机制。方法:采用腺嘌呤造模,设空白组、模型组、治疗1、2组。结果:治疗1、2组肾脏病理改变较模型组轻,尿素氮、肌酐、尿酸、PDGF表达较模型组低(P<0.05);治疗1组bFGF表达较模型组减少(P<0.05)。结论:大黄藿苓汤对腺嘌呤致慢性肾衰大鼠肾脏有保护作用,且早期用药优于晚期用药。其机制可能是抑制PDGF、bFGF表达。
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| 关 键 词： | 大黄藿苓汤 腺嘌呤 慢性肾衰 PDGF bFGF |
| 文章编号： | 1000-3649（2007）02-0026-03 |
| 修稿时间： | 2006-10-11 |
Effects of Da Huang Huo Ling Tang on the expression of PDGF.bFGF in Rats with Renal failure caused by Adenine |
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| Yang Youxin,Han shunpin,Han Youxing,Yuan Caosheng,Yang Man. Effects of Da Huang Huo Ling Tang on the expression of PDGF.bFGF in Rats with Renal failure caused by Adenine[J]. Journal of Sichuan of Traditional Medicine, 2007, 25(2): 26-28 |
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| Authors: | Yang Youxin Han shunpin Han Youxing Yuan Caosheng Yang Man |
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| Affiliation: | TianJing university of Traditional Chinese Medicine ( TianJing 300193, China |
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| Abstract: | Objective:It is to explore the protective function of Da Huang Huo Ling Targ on Chronic Renal Failure of rat .Method:Build the model by using adenine.Divide the models into normal group,model group,medicated group 1 and medicated group 2.Result:The pathology changes of the medicated group 1 and 2 were lighter than the control group.Blood Urea Nitrogen(BUN),creatinine and uric acid are lower than the model control group(P<0.05).bFGF expressions in medicated group 1 were less than that it in model group(P<0.05)?Conclusion:Da Huang Huo Ling Tang has protective function on Chronic Renal Failure in rat kidney caused by adenine.Early medication is more effective than later period.Its mechanism can be the restraint in PDGF and bFGF expressions. |
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| Keywords: | PDGF bFGF |
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