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Multiple sclerosis coinciding with Machado-Joseph disease |
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| Authors: | J. E. Röhl J. D. Lünemann C. Zimmer R. Zschenderlein J. M. Valdueza |
| Affiliation: | (1) Department of Neurology, University Hospital Charité Humboldt University, Schumannstrasse 20/21, 10098 Berlin, Germany;(2) National Institutes of Health, NINDS Cellular Immunology Section, Bethesda, MD, USA;(3) Neuroradiological Section of the Department of Radiology, University Hospital, University Leipzig, Germany;(4) Department of Neurology, Bad Segeberger Kliniken, Bad Segeberg, Germany |
| Abstract: | Abstract Although inflammatory demyelination is considered to be the key feature in multiple sclerosis (MS) pathogenesis, histopathological investigations and MRI studies recently highlighted the extent of neuronal damage that occurs even in the early stages of the disease. We report the unusual case of a patient with Machado-Joseph disease (MJD; spinocerebellar ataxia (SCA) III) and discuss this coincidence in light current pathogenetic paradigms of CNS autoimmunity. |
| Keywords: | Multiple sclerosis (MS) Machado-Joseph disease (MJD) Neurodegeneration Chronic inflammatory CNS disease |
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