胃癌根治术后复发的相关因素分析

目的 探讨影响胃癌根治术后复发转移的因素.方法 回顾性分析50例胃癌患者根治术后肿瘤复发转移的情况,并采用Logistic进行单因素和多因素回归分析.结果 50例患者平均复发时间为胃癌根治术后18.4个月;半年内复发14例（28.0%）,半年至1年内复发12例（24.0%）,2年内复发15例（30.0%）,3年内复发6例（12.0%）,3年以上复发3例（6.0%）;早期复发41例（82.0%）明显高于晚期复发9例（18.0%）（X2=6.45,P〈0.01）;单因素分析表明,原发灶部位、肿瘤大小、TNM分期、分化程度、Borrmann分型等是影响胃癌根治术后复发转移的因素（P〈0.01）;Logistie回归多因素分析,显示肿瘤大小、术后病理 TNM分期和辅助化疗是影响胃癌根治术后复发转移的独立因素（P〈0.01）.结论胃癌术后局部复发多在2年内发生,肿瘤大小、肿瘤病理分期、辅助化疗为影响胃癌局部复发的独立因素.

Analysis of influencing factors of recurrence and metastasis in patients with gastric cancer after radical operation

Objective To explore the influencing factors of recurrence and metastasis of gastric cancer after radical operation.Methods The recurrence and metastasis status of 50 patients with gastric cancer underwent the radical gastrectomy were retrospectively analyzed.Logistic multiple regression was used for univariate regression analysis or multivariate regression analysis.Results The average time of recurrence was 18.4 months in 50 cases with gastric cancer after radical operation; The rate of recurrence was 14 cases (28.0%)、12 cases (24.0% )、15 cases (30.0% )、6 cases (12.0% )、3 cases (6.0% ) within six months ,0.5-1 year、1～2 years、2～3 years >more than 3 years respectively; The early recurrence in 41 cases (82.0% ) were significantly higher than the late recurrence of 9 cases (18.0%) (X2 = 6.45,P <0.01) ;The univariate regression analysis indicated that original tumor site.,tumor size,TNM stage、 degree of differentiation,Bomnann classification were influencing factors of recurrence and metastasis (P <0.01); Logistic regression multivariate analysis showed tumor size、pathological TNM staging and adjuvant chemotherapy in gastric cancer were the independent influencing factors (P<0.01).Conclusion Most recurrences would happen within 2 years after radical resection for gastric carcinoma;The tumor size、 tunior pathological stages and adjuvant chemotherapy extent were independent correlation factors of locally recurrent gastric carcinoma.