细胞因子在小儿肺炎支原体肺炎发病机制中的研究进展

细胞因子及细胞免疫在肺炎支原体肺炎的发病机制中发挥重要的作用.研究显示肺炎支原体感染时,白介素-4(interleukin-4,IL-4)、干扰素-γ、IL-6、IL-13浓度增高,IL-10浓度降低.IL-2、IL-8、肿瘤坏死因子-α浓度变化各研究结果仍有分歧,仍需进一步深入探讨.通过临床监测多种细胞因子的浓度改变,能够为明确诊断肺炎支原体肺炎、判断感染轻重、预测预后提供依据,为今后肺炎支原体肺炎开展免疫治疗提供理论基础.

Cytokines in the pathogenesis of mycoplasma pneumoniae pneumonia in children

Cytokines and cellular immunity play a major role in the pathogenesis of mycoplasma pneumoniae pneumonia(MPP).Studies have shown that mycoplasma pneumoniae infection,the concentrations of interleukin(IL)-4,interferon-γ,IL-6 and IL-13 increased,but the concentration of IL-10 decreased.The concentrations of IL-2,IL-8 and tumor necrosis factor-α have various results which still need further discussion.Through clinical monitoring of a variety of cytokines by the changes of concentrations,it can confirm the diagnosis of MPP,determine the severity of infection,provide the basis for prognosis and provide the theoretical basis for immunotherapy of MPP.