Effects of the nootropics piracetam and GVS-111 on voltage-dependent ion channels of neuronal membranes |
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| Authors: | E I Solntseva Yu V Bukanova R U Ostrovskaya T A Gudasheva T A Voronina V G Skrebitskii |
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| Institution: | (1) Research Institute of the Brain, Russian Academy of Medical Sciences, Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | The effect of two nootropics, piracetam and N-phenylacetyl-L-prolyglycine ethyl ester (GVS-111), is studied by measuring high-threshold
K+ and Ca2+ currents in isolated snail neurons using a two-microelectrode patch-clamp technique. Piracetam and GVS-111 are shown to reduce
the amplitude of both the K+ and the Ca2+ (to a lesser extent) current. The threshold concentrations for GVS-111 and piracetam are 10−9-10−8 M and 1–5×10−4 M, respectively. It is assumed that the antiamnestic effect of the nootropics is partially mediated by a blockade of ion
channels of the neuronal membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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2, pp. 151–155, February, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences |
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| Keywords: | high-threshold Ca 2+ channels high-threshold K + channels nootropic drugs snail neurons |
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