正常孕妇不同孕期及产后常规凝血功能检测指标参考区间调查

目的:通过对我院正常孕妇在不同孕期及产后凝血功能指标的分析,建立本实验室孕妇在不同孕期及产后常规凝血试验参考区间.方法:应用日本Symex-CA500全自动血凝分析仪对凝血四项:凝血酶原时间(PT),活化部分凝血酶原时间(APTT),纤维蛋白原(FIB)浓度,凝血酶时间(TT)进行检测.结果:孕早期及产后72h凝血四项结果与健康对照组差异无统计学意义(P>0.05);孕中期、孕晚期PT、APTT较健康对照组下降,差异有统计学意义(P<0.05-0.01),FIB较健康对照组显著升高,差异有统计学意义(P<0.01),TT与健康对照组差异无统计学意义(P>0.05).结论:孕妇随孕期延长血液逐渐呈现高凝状态,产后72h趋于正常,针对自己实验室的具体实验条件、仪器、试剂等相关因素,建立本实验室正常孕妇不同孕期及产后常规凝血试验参考区间,对凝血指标进行动态检测,对于分娩过程中或产后大出血及其他并发症的预防和治疗有重要意义.

The Survey of Normal Pregnant Women's Routine Blood Coagulation Reference Interval in Different Periods and Post Partum

Objective: To establish our lab’s reference interval of routine blood coagulation in different periods and post partum by analysing their blood coagulation indices.Method: The prothrombin time(PT),activated partial thrombopastin time(APTT),fibrinogen(FIB) and thrombin time(TT) were detected by using the hemagglutinin analyzer.Result: The results of early pregnancy and 72 hours after delivery have no significant difference(P>0.05) compared with the healthy control group.The levels of PT and APTT in middle and late pregnant were lower than the health control group and showed statistically significant(P<0.050.01).The FIB was obviously higher and showed significant difference(P<0.01) compared with the healthy control group.There was no significant difference in TT level between the two groups.Conclusion: The blood of pregnant women is in a hypercoagulable state before delivery and it returns to normal at 72 hours after delivery.Dynamic detection of four indices of blood coagulation in connection with our lab’s condition,anglyzer,reagent,establishing our lab’s reference interval of routine blood coagulation in normal perinatal women has important clinical significance in monitoring and prevention of postpartum hemorrhage in lying-in women and in evaluation of their prognosis.