他克莫司联合糖皮质激素治疗成人特应性皮炎的疗效研究

目的:探讨他克莫司联合糖皮质激素治疗成人特应性皮炎疗效.方法:将本院近期门诊收治的60例成人特应性皮炎患者随机分两组,对照组30例单行糖皮质激素治疗,实验组30例联合他克莫司,对比两组患者治疗后的脱屑、红斑、毛细血管扩张、皮肤萎缩、丘疹脓疱、色素沉着等皮损积分变化,并统计患者总有效率(显效+有效).结果:两组内比较,治疗后第4周患者各项皮损积分均优于治疗前 (P<0.05);而两组间相比,实验组患者的各项皮损积分明显优于对照组 (P<0.05),且实验组患者的总有效率为93.3%,明显高于对照组的80.0%(p<0.05).结论:应用他克莫司联合糖皮质激素早期治疗成人特应性皮炎,可以显著改善皮损积分变化,有效提高患者的预后.

Tacrolimus Combined with Corticosteroids in the Treatmentof adult Atopic Dermatitis Efficacy Study

Objective: To investigate the tacrolimus combined with corticosteroids in the treatment of adult atopic dermatitis in the method and curative effect.Method: the recent outpatient hospital treated 60 cases of adult patients with atopic dermatitis were randomly divided into 2 groups,30 cases in the control group specific glucocorticoid treatment,the experimental group 30 cases combined with tacrolimus,compared two groups of patients after treatment of scaling,erythema,telangiectasia,papules,pustules,skin atrophy,pigmentation and other skin lesions integral change,and statistical total efficiency(markedly + effective).Result: of the two group,after fourth weeks of treatment on the patients with lesions integral are better than before treatment(P < 0.05);and the two groups compared,the patients in experimental group the various lesions integral was significantly better than the control group(P < 0.05),and the patients in the experimental group in the total efficiency was 93.3%,significantly higher than that in control group.80%(P < 0.05).Conclusion:the application of tacrolimus combined with glucocorticoid early in adult patients with atopic dermatitis,can significantly improve skin lesions integral change,effectively improve the prognosis of the patients.