| 间充质干细胞治疗炎症性心肌病的研究进展 |
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| 引用本文： | 瞿海龙,边剑飞,周英莲,杨伟红,麻晓静,梁璐.间充质干细胞治疗炎症性心肌病的研究进展[J].河北职工医学院学报,2012,29(3):44-48. |
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| 作者姓名： | 瞿海龙 边剑飞 周英莲 杨伟红 麻晓静 梁璐 |
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| 作者单位： | 1. 河北大学附属医院急诊科,河北,保定,071000
2. 保定市南市区妇幼医院,河北,保定,071000 |
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| 摘 要： | 炎症性心肌病是一种慢性渐进性疾患,传统的治疗方法不能改变其心衰的结局,寻求有效治疗策略成为目前研究重点。众多证据表明干细胞移植可改善心功能,其中间充质干细胞（mesenchymal stem cells,MSCs）还具有免疫抑制特性,使其在治疗炎症性心肌病时具有独特优势。现就炎性感染如何诱发MSCs的功能、如何促使其归巢到受损心肌、静脉应用MSCs的可行性作一综述。
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| 关 键 词： | 间充质干细胞 炎症性心肌病 归巢 |
Research progress of mesenchymal stem cells treating inflammatory cardiomyopathy |
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| JU Hailong
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BIAN Jianfei
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ZHOU Yinglian
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YANG Weihong
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MA Xiaojing
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LIANG Lu.Research progress of mesenchymal stem cells treating inflammatory cardiomyopathy[J].Journal of Hebei Medical College for Continuing Education,2012,29(3):44-48. |
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| Authors: | JU Hailong BIAN Jianfei ZHOU Yinglian YANG Weihong MA Xiaojing LIANG Lu |
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| Institution: | 1. Emergency Department, Affiliated Hospital of Hebei University, Baoding 071000, China; 2. Woman and Child Care Service Centre of Baoding Southern Downtown, Baoding 0 71000, China) |
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| Abstract: | Inflammatory cardiomyopathy usually has a progressive course, conventional therapy can not alert the pathological process for heart failure, merging for alternative interventional strategies is necessary. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function, Mesenchymal stem cells （MSCs） have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed. |
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| Keywords: | mesenchymal stem cells inflammatory cardiomyopathy homing |
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