| 肿瘤坏死因子α抑制剂的免疫原性 |
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| 引用本文： | 吴婵媛,李梦涛,曾小峰.肿瘤坏死因子α抑制剂的免疫原性[J].中华临床免疫和变态反应杂志,2009(3):210-215. |
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| 作者姓名： | 吴婵媛 李梦涛 曾小峰 |
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| 作者单位： | 中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京100032 |
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| 摘 要： | 近年来肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）抑制剂广泛应用于风湿免疫性疾病的治疗,但临床医生对其免疫原性尚认识不足。越来越多的证据表明,TNF-α抑制剂的免疫原性对TNF-α抑制剂的药代动力学和临床疗效等均有影响。本文对TNF-α抑制剂免疫原性的产生机制、形成特点和监测方法等进行综述,相信加强监测和减少TNFα抑制剂的免疫原性具有重要的临床意义。
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| 关 键 词： | 肿瘤坏死因子-α抑制剂 免疫原性 |
Immunogenicity of Tumor Necrosis Factor-alpha Inhibitors |
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| WU Chan-yuan,LI Meng-tao,ZENG Xiao-feng.Immunogenicity of Tumor Necrosis Factor-alpha Inhibitors[J].Chinese Journal of Allergy and Clinical Immunology,2009(3):210-215. |
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| Authors: | WU Chan-yuan LI Meng-tao ZENG Xiao-feng |
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| Institution: | (Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science ＆ Peking Union Medical College, Beijing 100032, China) |
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| Abstract: | To date, millions of rheumatic patients have been treated with tumor necrosis factor-α （TNF-α） inhibitors for various indications. It is becoming increasingly clear that TNF-αinhibitors can be immunogenic, which may reduce efficacy or induce adverse effects. With the development of detective methods, we have an opportunity to study the anti-antibody immune response in human, and to manipulate immunogenicity in the future. |
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| Keywords: | tumor necrosis factor-alpha inhibitors immunogenicity |
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