第1、2代抗环瓜氨酸肽抗体对类风湿关节炎诊断价值的比较

目的比较第1代与第2代抗环瓜氨酸肽（anti-cyclic citrutlinated pepfide，CCP1，CCP2）抗体对类风湿关节炎（rheumatoid arthritis，RA）的诊断价值。方法对129份RA、153份其他风湿性疾病和94份健康对照血清进行检测。类风湿因子（rheumatoid factor，RF）检测采用乳胶间接凝集法，抗CCP1和抗CCP2抗体检测采用酶联免疫吸附法。结果对RA的诊断敏感性，抗CCP2抗体高于RF和抗CCP1抗体，分别为67．4％、46．5％和46．5％，差异有显著性意义（P=0．001）；抗CCP1和抗CCP2抗体对RA的诊断特异性均为94．7％，而RF的诊断特异性仅为77．7％，差异亦有显著性意义（P〈0．001）。结论抗CCP2抗体对RA诊断有较好的敏感性和较高的特异性。

Comparison of First- and Second-generation Anti-cyclic Citrullinated Peptide Antibodies Assays for Detecting Rheumatoid Arthritis

Objective To analyze the diagnostic value of the second generation anti-cyclic eitrullinated peptide （CCP2） autoantibody in rheumatoid arthritis （RA）, comparing with the first generation of anti-CCP （CCP1） antibody. Methods Samples from RA 129 cases, other non-RA rheumatic disease 153 cases, and 94 healthy subjects were tested. Anti-CCP1 and anti-CCP2 antibodies were detected by enzyme linked immunosorbent assay test. Results Anti-CCP2 antibody was more sensitive than anti-CCP1 autoantibody significantly for rheumatoid arthritis （46.5% vs 67.4%, P = 0.001）. Their specificities were both 94.7%. Conclusion Anti-CCP2 antibody showed more sensitively and higher specificity for rheumatoid arthritis.