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不同化学制剂及复配对户尘螨的药效
引用本文:沈莲,;孙劲旅,;张洪杰,;陈军,;王洪超.不同化学制剂及复配对户尘螨的药效[J].中华临床免疫和变态反应杂志,2009(4):244-248.
作者姓名:沈莲  ;孙劲旅  ;张洪杰  ;陈军  ;王洪超
作者单位:[1]中国科学院研究生院,北京100049; [2]中国医学科学院北京协和医学院北京协和医院变态反应科,北京100730; [3]军事医学科学院微生物流行病研究所,北京100071; [4]中国科学院动物进化与系统学重点试验室中国科学院动物研究所,北京100101; [5]北京亿家健科技有限公司研发部,北京100190
基金项目:基金项目:科技部卫生行业科研项目:中国主要过敏性疾病流行病学研究及规范化防治(200802001);国家基础科学人才培养基金动物分类学特殊学科点(NSFC-J0630964/J0109):
摘    要:目的通过有效制剂的复配以降低单一化学抑螨/杀螨剂的浓度并保证尘螨防治效果。方法参照国标GB13917.1-92规定的方法,选择6种化学制剂或其复配制剂,对户尘螨(Dermatophagoides pteronyssinus)进行室内药效比较。结果喷药24小时后,1.8%苯甲酸苄酯的杀螨率达100%;4%八硼酸二钠+0.05%苄索氯铵+0.9%苯甲酸苄酯复配制剂的杀螨率为88%;其余4种制剂杀螨率均低于70%,效果不佳。结论1.8%苯甲酸苄酯的急性杀螨效果最好,其次为4%八硼酸二钠+0.05%苄索氯铵+0.9%苯甲酸苄酯复配制剂。提示在保持一定杀螨效果的基础上,复配可降低单一化学抑螨/杀螨剂的使用浓度,并规避了苯甲酸苄酯的非水溶性质,可通过广泛长期使用而达到尘螨变应原的防治效果。

关 键 词:户尘螨  抑螨/杀螨剂  药效试验  变应原防治

Efficacy of Various Acaricides and Compositional Formula against Dermatophagoides pteronyssinus (Acari: Astigmata)
Institution:SHEN Lian, SUN Jin-lii, ZHANG Hong-jie, CHEN Jun, WANG Hong-chao (Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China)
Abstract:Objective To decrease the concentration of single cheinical acaricide and certify the efficacy of dust mite control by dispensing effective acaricides. Methods The efficacy of 6 kinds of selected chemical acaricides and their compositional formula against Dermatophagoides pteronyssinus was tested under laboratory conditions according to the regulation method from GB 13917.1-92. Results After 24 hours of spraying acaricides, the acaricidal efficacy of 1.8% benzyl benzoate reaches to 100%; the efficiency of the formula of 4% disodium octaborate tetrahydrate, 0.05% hyamine and 0.9% benzyl benzoate is 88%; the effectiveness of the other four acaricides are all under 70%. Conclusions 1.8% benzyl benzoate has shown the best immediate effectiveness among these 6 acaricides, followed by the formula of 4% disodium octaborate tetrahydrate, 0.05% hyamine and 0.9% benzyl benzoate. The results indicate that the compositional formula of acaricides can decrease the concentration of single acaricide and avoid the water-insolubility of benzyl benzoate without compromising practical acaricidal efficacy against dust mites. The formula can control dust mite allergen through general longterm using in houses .
Keywords:Dermatophagoides pteronyssinus  acaricides  pharmacodynamic test  allergen control
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