| 法莫替丁分散片的研制及体外溶出特性 |
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| 引用本文： | 张建春,王原,陈鼎继,王春宏,温亚旭.法莫替丁分散片的研制及体外溶出特性[J].中国药房,2002,13(8):473-474. |
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| 作者姓名： | 张建春 王原 陈鼎继 王春宏 温亚旭 |
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| 作者单位： | 解放军第一医院药剂科,兰州市730030 |
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| 摘 要： | 目的 :研制法莫替丁分散片 ,并考察其体外溶出特性。方法 :采用正交设计方法优选出制备的最佳条件。结果 :本品在1min内可完全崩解 ;体外溶出度表明 ,T50=0 56min。结论 :用优选处方制备的法莫替丁分散片比市售片崩解快 ,分散均匀。
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| 关 键 词： | 法莫替丁 分散片 正交设计 溶出度 |
| 文章编号： | 1001-0408(2002)08-0473-02 |
| 修稿时间： | 2001年10月8日 |
Preparation and in Vitro Dissolution Characteristics of Famotidine Dispersible Tablets |
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| ZHANG Jianchun,WANG Yuan,CHEN Dingji,WANG Chunhong,WEN Yaxu.Preparation and in Vitro Dissolution Characteristics of Famotidine Dispersible Tablets[J].China Pharmacy,2002,13(8):473-474. |
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| Authors: | ZHANG Jianchun WANG Yuan CHEN Dingji WANG Chunhong WEN Yaxu |
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| Abstract: | OBJECTIVE:To study the preparation of famotidine dispersible tablets and to observe the dissolution characteristics in vitro METHODS:To optimize the conditions for preparation by orthogonal design RESULTS:The tablets could completely disintegrate within 1 min;In vitro dissolution test showed T50=0 56min CONCLUSION:In comparison with commercial famotidine tablets,the dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal |
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| Keywords: | famotidine dispersible tablet orthogonal design dissolubility |
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