| CD90蛋白的研究进展 |
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| 引用本文： | 赵何伟,王太洪,郑苏文,孙静锋,张业伟. CD90蛋白的研究进展[J]. 中国普外基础与临床杂志, 2012, 19(9): 104-108 |
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| 作者姓名： | 赵何伟 王太洪 郑苏文 孙静锋 张业伟 |
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| 作者单位： | 1. 南京医科大学研究生院 江苏南京210029
2. 南京医科大学附属肿瘤医院普外科 江苏南京210009 |
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| 基金项目： | 国家自然科学基金专项基金项目，江苏省自然科学基金，江苏省医学重点人才基金 |
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| 摘 要： | 目的总结CD90蛋白的研究进展。方法查阅近年来国内外有关CD90蛋白研究的文献并作综述。结果 CD90蛋白与细胞-细胞,以及细胞-细胞质间的作用有关;可促进神经轴突生长和神经再生,诱导胸腺细胞和间质细胞凋亡,参与细胞黏附、外渗和转移,调节纤维化;可作为癌症干细胞的候选标志物。结论 CD90蛋白在多种疾病的发生和发展过程中起重要作用,为肿瘤诊治提供了新的分子治疗靶点。
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| 关 键 词： | CD90蛋白 免疫球蛋白 干细胞 分子标志物 |
The Research Progress of CD90 Protein |
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| ZHAO He-wei , WANG Tai-hong , ZHENG Su-wen , SUN Jing-feng , ZHANG Ye-wei. The Research Progress of CD90 Protein[J]. Chinese Journal of Bases and Clinics In General Surgery, 2012, 19(9): 104-108 |
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| Authors: | ZHAO He-wei WANG Tai-hong ZHENG Su-wen SUN Jing-feng ZHANG Ye-wei |
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| Affiliation: | 1. Graduate School of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China;2. Department of General Surgery,Affiliated Cancer Hospital of Nanjing Medical University,Nanjing 210009,Jiangsu Province,China |
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| Abstract: | Objective To summarize the research progress of CD90 protein.Methods The demestic and international published literatures related to CD90 protein in recent years were collected and reviewed.Results CD90 protein was involved in the cell-cell and cell-cytoplasm function.CD90 protein could promote axons growth and neural regeneration,and could induce apoptosis of thymus gland cells and stromal cells.CD90 protein participated in cell adhesion,extravasation and transfer,and the regulation of fibrosis.CD90 protein was a potential marker for cancer stem cells.Conclusion CD90 protein is very important in development of many diseases,and can provide a new molecular target to diagnose and treat neoplasms. |
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| Keywords: | CD90 protein Immunoglobulin Stem cells Molecular marker |
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