| 对—羟基苯甲醛和对—羟基苯甲酸对单胺氧化酶活性的影响 |
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| 引用本文： | 徐惠波,陈晓光.对—羟基苯甲醛和对—羟基苯甲酸对单胺氧化酶活性的影响[J].中国药理学通报,1992,8(3):224-226. |
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| 作者姓名： | 徐惠波 陈晓光 |
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| 作者单位： | 吉林省中医中药研究院中药所药理室 长春130021
(徐惠波，陈晓光，李延忠，孙晓波)，吉林省中医中药研究院中药所药理室 长春130021(王本祥) |
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| 摘 要： | 小鼠灌服对一羟基苯甲醛(PHBAD)和对一羟基苯甲酸(PHBZA)能明显抑制脑和肝组织的单胺氧化酶(MAO)活性,且对MAO—B的抑制作用强于MAO—A。PHBAD(200～400mg·kg~(-1)对小鼠脑MAO—B抑制作用强于PHBZA。体外实验证明,二者对MAO—B的抑制作用随浓度增加而明显增强。另外,PHBAD对MAO—B呈竞争型抑制;对MAO—A呈混合型抑制;而PHBZA对MAO-B、MAO—A均呈混合型抑制。
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| 关 键 词： | 对-羟基苯甲醛 对-羟基苯甲酸 单胺氧化酶 鹿茸 |
Effects of monoamine oxidase activity on p -hydroxybenzaldehyde and p -hydroxybenzoic acid |
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| XU Hui - Bo. CHEN Xiao- Guang,LI Yan -Zong et al.Effects of monoamine oxidase activity on p -hydroxybenzaldehyde and p -hydroxybenzoic acid[J].Chinese Pharmacological Bulletin,1992,8(3):224-226. |
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| Authors: | XU Hui - Bo CHEN Xiao- Guang LI Yan -Zong |
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| Abstract: | It was demostrated that p - hydroxybenzoic acid and p - hydroxy-bcnaldehyde exhibited significatly inhibitory effect on monoamine oxidase (MAO) activity in liver and brain tissues when they were given orally to mice at doses of 200 ~ 400mg. kg-1. They possessed higher potency for inhibiting MAO B activity and lower potency for inhibiting MAO A activity. In vitro experiment demostrated that p - hydroxyben-
zaldehyde showed stronger inhibitory action on MAO B activity than p -hydroxybenzoic acid. In addition, the inhibitory action of phydroxybenzaidehvde on MAO B was competitive, and that on MAO A was mixed. But action of p -hydroxybenzoic acid on MAO B and MAO - A was mixed inhibition. |
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| Keywords: | p - hydroxyben-zaldehyde phydroxybenzoic acid monoamine oxidase pilose antler |
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