软骨终板钙化与椎间盘退变关系的实验研究

目的　研究椎体软骨终板钙化与椎间盘退变的关系。　方法　通过切除２０ 只兔颈椎棘上、棘间韧带及分离颈椎后旁两侧肌肉造成颈椎力学上的失稳而诱导了颈椎间盘退变动物模型。在形态学上评定颈椎间盘退变程度,测定不同退变程度椎间盘软骨终板钙化层与非钙化层厚度。　结果　软骨终板钙化层厚度与椎间盘退变程度呈高度正相关性（ｒ＝ ０－９２） 。　结论　软骨终板的钙化可能是椎间盘退变的启动和促进因素

The relationship between cartilage end-plate calcification and disc degeneration: an experimental study

Objective To study the relationship between cartilage end plate calcification and intervertebral disc degeneration. Methods An experimental model of cervical disc degeneration in rabbits was established by resection of cervical supraspinous and interspinous ligaments and detachment of the posterior paravertebral muscles from cervical vertebrae. Mechanical instability in the cervical spine elicited by this surgical intervention accelerated the process of intervertebral disc degeneration. The degrees of intervertebral disc degeneration were graded morphologyically. The thickness of the calcified layer and the uncalcified layer of the cartilage end plate was measured in each degenerated cervical disc. Results A positive correlation existed between the thickness of the calcified layer of the cartilage end plate and the degree of the cervical disc degeneration( r =0 92). Conclusion The calcification of the cartilage end plate could initiate and promote intervertebral disc degeneration.