Workshop report on some new ideas about the treatment of systemic lupus erythematosus |
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Authors: | Linnik M Staines N A Berden J Isenberg D A |
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Affiliation: | La Jolla Pharmaceuticals, San Diego, California, USA. |
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Abstract: | Our increased understanding of the pathogenesis of systemic lupus erythematosus is leading to new ideas about its therapy. In this session of the workshop the use of LJP 394 a B cell toleragen and the use of an anti-CD20 monoclonal antibody were discussed in some detail. Their rationale and early clinical results were reviewed; both have shown encouraging clinical and serological benefit. Definitive double-blind clinical trials are still, however, awaited. In addition, the intriguing notion of using a nasal instillation of a histone peptide was described and early work in an experimental model presented. |
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