| 有机锡配合物抗癌活性的研究 |
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| 引用本文： | 肖箫,曹红梅,徐坤.有机锡配合物抗癌活性的研究[J].吉林医药学院学报,2016(1):10-12. |
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| 作者姓名： | 肖箫 曹红梅 徐坤 |
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| 作者单位： | 吉林医药学院,吉林 吉林,132013 |
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| 基金项目： | 吉林市科技计划项目(20156426) |
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| 摘 要： | 目的 合成有机锡羧酸酯化合物并测试抗癌活性. 方法 以Ph2 CONHCOOH为配体,与Ph3 SnOH合成(Ph)3Sn(Ph2CONHCOO)](化合物1);通过MTT法测定化合物1对MCF-7细胞的抗癌活性. 结果 小剂量的化合物1便可以对MCF-7细胞产生很高的抗癌活性. 结论 化合物1具有作为抗癌药物的潜质.
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| 关 键 词： | 有机锡羧酸酯 抗癌活性 MTT法 |
Study on antitumour activity of organotin carboxylate [ ( Ph ) 3 Sn ( Ph2 CONHCOO) ] |
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| Abstract: | Objective To synthesize an organotin carboxylate and observe its antitumour activity. Methods Com-plex One was synthesized by Ph2 CONHCOOH and Ph3 SnOH,and its antitumour effect against MCF-7 was tested by MTT. Results The MTT results showed that complex one in micro-dose possessed high antitumour activity against MCF-7. Conclusion The complex one has the potential to be anti-cancer drug. |
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| Keywords: | organotin carboxylate antitumour activity MTT |
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