电针对大鼠脑局部缺血-再灌流损伤的保护作用

再灌流前电针“环跳”穴３０ｍｉｎ，观察对左大脑中动脉（ＭＣＡ）缺血 再灌流模型大鼠早期运动功能、自由基代谢、脑水肿及神经电生理活动的影响。结果：缺血再灌＋针刺组大鼠再灌流后神经功能缺损状况有较明显的改善，病灶侧脑组织过氧化物歧化酶（ＳＯＤ）活性及丙二醛（ＭＤＡ）含量恢复到接近假手术对照组的水平。皮层体感诱发电位（ＳＥＰ）测量表明缺血侧Ｐ１潜伏期及Ｐ１ Ｎ１波幅亦有显著性改善。结果表明：于再灌流前电针处理对本模型脑缺血 再灌流损伤有保护作用

Protective Effects of Electro Acupuncture on Focal Cerebral Ischemia Reperfusion Injury in Rats

Using a rat model of reversible regional cerebral ischemia, the effects of electro-acupuncture were examined at the point of “huantiao” before reperfusion. The left middle cerebral artery(MCA)occlusion was achieved with a nylon filament placed into the vessel. The results showed that animals in the acupuncture treatment group had a significantly regaining of movement ability than that in the ischemia reperfusion group. The mean levels of malondialdehyde(MDA)concentration and superoxide dismutase(SOD)activity of the ischemic hemisphere in the acupuncture treatment group returned to the level of sham control group. The cortical somatosensory evoked potentials(SEP)measured ipsilaterally on the cortex of ischemic hemisphere showed that with electro acupuncture,both P1 latency and P1-N1 amplitude improved significantly. The results suggested that electro-acupuncturing at the point of “huantiao” has beneficial effects on focal cerebral ischemia-reperfusion injury in rats.