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| Adipose tissue,systematic inflammation,and neurodegenerative diseases | |
| 作者姓名： | Ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel F.Frihling Patrícia Souza e Silva Luiz Filipe R.Nde Moraes Ludovico Migliolo |
| 作者单位： | S-Inova Biotech;Programa de Pós-Gradua??o em Biologia Celular e Molecular |
| 基金项目： | supported by the Brazilian funding agencies CNPq,and FUNDECT (to LM) |
| 摘 要： | Obesity is associated with several diseases, including mental health. Adipose tissue is distributed around the internal organs, acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues. Excessive nutritional intake results in hypertrophy and proliferation of adipocytes, leading to local hypoxia in adipose tissue and changes in these adipokine releases. This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammato... |
| 关 键 词： | ADIPOSITY anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease NEUROINFLAMMATION |
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