低血糖对青年2型糖尿病患者心血管事件的影响

目的：探讨低血糖对青年2型糖尿病患者心血管事件的影响。方法：采用回顾性研究方法,2014年8月到2016年6月选择在我院内分泌科诊治的青年2型糖尿病患者360例,收集所有患者的病历资料与血压样本检测结果,记录低血糖发生情况与调查相关因素,随访心血管事件发生情况。结果：360例患者中发生低血糖20例,发生5.6%。根据2型糖尿病患者是否发生低血糖分为低血糖组(n=20)与对照组(n=340),两组的HDL-C、HbA1c、LDL-C、TG、TC值等对比无明显差异(P>0.05),不过低血糖组的SCr、CRP、CK值等都明显高于对照组(P<0.05)。通过采用Logistic回归分析发现,引起低血糖的主要因素为CRP、病程、CK以及年龄。所有患者随访6个月,低血糖组的不稳定性心绞痛、心力衰竭、靶血管血运重建、猝死等心血管事件发生率为40.0%,明显高于对照组的3.8%(P<0.05)。结论：青年2型糖尿病患者存在低血糖状况,主要发病因素包括年龄、病程、CRP、CK等,可导致心血管事件的增加,在临床上要积极进行预防性控制。

Effects of hypoglycemia on cardiovascular events in young patients with type 2 diabetes

Objective: To investigate the effects of hypoglycemia on cardiovascular events in young patients with type 2 diabetes. Methods: Used a retrospective study, From August 2014 to June 2016, 360 young patients with type 2 diabetes in our hospital department of Endocrinology were selected, The sample data were collected and recorded the blood pressure test results for all patients, The hypoglycemia were recorded and were to investigate the factors, followed-up the occurrence of cardiovascular events. Results: There were 20 patients of hypoglycemia in the 360 patients, the occur rate was 5.6%. Accorded to whether hypoglycemia in patients with type 2 diabetes were divided into hypoglycemia group (n=20) and control group (n=340). There no significant difference in HDL-C, HbA1c, LDL-C, TG and TC values were compared between the two groups (P>0.05), but the SCr, CRP,CK value in the hypoglycemia group were significantly higher than the control group (P< 0.05). Logistic stepwise regression analysis showed that age, course of disease, CRP, CK were the independent risk factors for the occurrence of hypoglycemia (P<0.05). All patients were followed up for 6 months, the incidence of unstable angina, heart failure, target vessel revascularization, sudden death and other cardiovascular events in the hypoglycemia group was 40%, so that was 3.8% in the control group (P<0.05). Conclusion:The prevalence of hypoglycemia is common in young patients with type 2 diabetes, the age, course of disease, CRP, CK are the independent risk factors for the occurrence of hypoglycemia that can lead to the increase of cardiovascular events, in the clinical should actively carry out preventive control