不稳定性心绞痛患者血管内皮生长因子水平变化 及其相关因素分析

目的 探究并分析不稳定型心绞痛患者血管内皮生长因子的水平变化及其相关影响因素。方法 选取 2014 年 12 月—2015 年 12 月我院收治的 60 例不稳定型心绞痛患者作为研究对象，并纳入心绞痛组，另选取同期收治的冠状动脉造影正常的 35 例胸痛患者纳入对照组。使用 Gensini 评分评价冠状动脉狭窄程度，通过测定反应性充血指数（RHI）评估外周动脉压，检测患者血清相关生化指标，并采用蛋白质芯片技术测定血清内皮生长因（VEGF）、血管形成蛋白-1（Ang-1）、血管形成蛋白-2（Ang-2）等水平。结果 两组的基线资料相比，心绞痛组较对照组 TG 水平更高，Gensini 评分更高，RHI 值更低（p 均＜0.05）；心绞痛组较对照组 Ang-2、VEGF 的水平有了显著的提高（p 均＜0.05），但 Ang-1 水平的差异无统计学意义（p＞0.05）；RHI、Gensini 评分和冠状动脉狭窄程度与血清 VEGF的水平密切相关（p 均＜0.05）。结论 不稳定心绞痛患者的 VEGF 水平显著提高，其水平与冠状动脉狭窄程度、Gensini 评分呈正相关，与 RHI 呈负相关。

Changes in Vascular Endothelial Growth Factor and Its Related Factors in Patientswith Unstable Angina Pectoris

ObjectiveThis study is intended to investigate and analyse the changes in vascular endothelial growth factor and its influential factors in patients with unstable angina pectoris. MethodsSixty patients diagnosed with unstable angina pectoris in our hospital during December 2014 to December 2015 were enrolled into the angina pectoris group, and another 35 patients who presented with chest pain but appeared normal in coronary angiography in the same period of time were enrolled into the control group. Artery stenosis was evaluated with theGensini Score, and peripheral artery pressure was measured with reactive hyperaemia index (RHI). Serum biochemical indices were measured, and protein chipswere utilised to assess the level of serum vascular endothelial growth factor (VEGF), angiogenesis protein-1 (Ang-1), vascular formation protein-2 (Ang-2). ResultsThe base line level of TG and Gensini score were higher and the RHI level are lower in the angina pectoris group (p<0.05). The level of Ang-2 and VEGF increased significantly (p<0.05), while the difference in Ang-1 is insignificant (p>0.05). RHI, Gensini score and artery stenosis are closely related to serum VEGF level (p<0.05).ConclusionThe level of VEGF in patients with unstable angina pectoris increasesignificantly, which is positively correlated with the degree of coronary artery stenosis and Gensini score, and negatively correlated with RHI.