血府逐瘀汤联合奥氮平治疗脑外伤致精神障碍患者的临床疗效

目的：探讨研究使用血府逐瘀汤与奥氮平联合治疗脑外伤所致的精神障碍患者的临床治疗效果。方法：将2012年10月至2015年12月我院收治的108例脑外伤所致的精神障碍患者根据随机数字表法分成研究组(54例)和对照组(54例),对照组采取内服奥氮平治疗,研究组在对照组的基础上服用有血府逐瘀汤制成的汤剂进行联合治疗。观察比较两组患者治疗后精神障碍的改善情况,采用阳性症状和阴性症状量表(positive and negative symptoms scale,PANSS)评定症状的改善情况,采用副反应症状量表(Treatment Emergent Symptom Scale,TESS)比较两组患者在治疗过程中出现的副反应情况,采用简明精神病评定量表(Brief Psychiatric Rating Scale,BPRS)评价两组患者的临床症状的改善情况,采用生活质量综合评定量表(GQOLI)评价比较两组患者治疗后生活质量的改善情况。结果：治疗后两组患者的PANSS评分均明显下降,且治疗后2周、4周、8周研究组患者的PANSS评分明显低于对照组,差异有统计学意义(P＜0.05)。治疗前后两组患者的副反应症状量表TESS评分之间的差异没有统计学意义(P＞0.05),且两组患者在治疗过程中出现的不良反应情况之间的差异没有统计学意义(P＞0.05)。治疗后研究组患者的BPRS量表评分均明显低于对照组,差异有统计学意义(P＜0.05)。治疗后研究组患者生活质量改善情况明显优于对照组,差异有统计学意义(P＜0.05)。结论：血府逐瘀汤联合奥氮平治疗是能够有效治疗脑外伤所致的精神障碍,缓解患者的精神障碍,改善患者的生活质量,疗效确切、安全,具有非常好的临床应用前景。

The clinical effects of Xuefuzhuyu Decoction combined with Olanzapine on mental disorders caused by traumatic brain injury

Objective: To investigate the clinical effects of Xuefuzhuyu Decoction combined with Olanzapine on mental disorders patients caused by traumatic brain injury.Methods: One hundred and eight mental disorders patients caused by traumatic brain injury were divided into the study group (54 cases) and the control group (54 cases) according to the random number table during October 2012 to December 2015. Patients in the control were treated with oral olanzapine and the study group were taking Xuefuzhuyu Decoction on the basis of the control group. The improvement of the situation for mental disorders were compared by PANSS.The side effects were compared between the two groups by TESS. The improvement of clinical symptoms were compared by BPRS and the improvement of the life quality after treatment were compared by GQOLI.Results: After treatment, the patient"s PANSS scores were significantly decreased, and 2 weeks, 4 weeks, 8 weeks after treatment, study group patients PANSS scores were significantly lower than the control group, the difference were statistically significant (P<0.05). There was no significant statistically different in TESS symptom scale score between the two groups (P>0.05), and the differences between the two groups of patients in adverse reactions during treatment was not statistically significant (P>0.05). After treatment, BPRS scale scores of patients in the study group were significantly lower than the control group, the difference was statistically significant (P<0.05). The improvement of life quality in the study group was much better than the control, the difference was statistically significant (P<0.05).Conclusion:Xuefuzhuyutang Decoction combined with Olanzapine therapy is effective in the treatment of mental disorders due to traumatic brain injury, it can relieve mental disorders, improve the quality of life of patients, and has a very good prospect of clinical application.