| Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury |
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| 作者姓名： | Chang-Bin Liu De-Gang Yang Jun Li Chuan Qin Xin Zhang Jun Liu Da-Peng Li Jian-Jun Li |
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| 作者单位： | Department of Rehabilitation Medicine;Department of Spinal and Neural Function Reconstruction;China Rehabilitation Science Institute;Department of Neurosurgery |
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| 基金项目： | supported by the National Natural Science Foundation of China, No. 82102676 (to CBL);a grant from Beijing Municipal Science & Technology Commission, No. Z171100001017076 (to JJL);National Key Research and Development Program, No. 2018YFF0301104 (to JJL);Research on Medical Protection Technology and Application of Induced Neural Stem Cells in the Treatment of Military Spinal Cord Injury, No. Z181100004118004 (to JL) |
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| 摘 要： | Based on the Wallerian degeneration in the spinal cord pathways, the changes in synaptic connections, and the spinal cord-related cellular responses that alter the cellular structure of the brain, we presumed that brain diffusion tensor imaging(DTI) parameters may change after spinal cord injury. However, the dynamic changes in DTI parameters remain unclear. We established a Beagle dog model of T10 spinal cord contusion and performed DTI of the injured spinal cord. We found dynamic changes in DT...
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| 关 键 词： | spinal cord injury diffusion tensor imaging CANINES PATHOPHYSIOLOGY cerebrospinal structures corticospinal tract magnetic resonance imaging anisotropic fraction apparent dispersion coefficient |
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