吡格列酮治疗2型糖尿病合并脑梗死患者临床疗效观察及对患者颈动脉超声的影响

目的：探讨吡格列酮治疗2型糖尿病合并脑梗死患者临床疗效观察及对患者颈动脉超声的影响。方法：选自我院于2015年1月~2016年3月期间收治的2型糖尿病合并脑梗死患者86例,依据随机数字表法随机分为观察组43例与对照组43例。对照组给予瑞舒伐他汀,观察组在对照组基础上结合吡格列酮。两组疗程均为4周。比较两组治疗疗效,治疗前后NIHSS评分、ADL评分、FPG、HbA1c、MT、颈动脉内膜斑块面积变化,及不良反应发生情况。结果：观察组治疗总有效率(90.70%)高于对照组(69.77%)(P<0.05)；两组NIHSS评分治疗后下降,而ADL评分增加(P<0.05)；观察组NIHSS评分治疗后低于对照组,而ADL评分高于对照组(P<0.05)；两组FPG和HbA1c治疗后下降(P<0.05)；观察组FPG和HbA1c治疗后低于对照组(P<0.05)；两组MT和颈动脉内膜斑块面积治疗后下降(P<0.05)；观察组MT和颈动脉内膜斑块面积治疗后低于对照组(P<0.05)；两组心电图、血常规、尿常规、肝肾功能均未见异常,且无明显不良反应。结论：吡格列酮治疗2型糖尿病合并脑梗死患者临床疗效显著,减少颈动脉内中膜厚度和颈动脉内膜斑块面积,值得研究。

Pioglitazone treatment of type 2 diabetes in patients with cerebral infarction and observe the effect on carotid ultrasound

Objective: To investigate the pioglitazone treatment of type 2 diabetes in patients with cerebral infarction and observe the effect on carotid ultrasound. Methods: selected from our hospital in January 2015 - March 2016 period with type 2 diabetes treated 86 patients with cerebral infarction, were randomly divided into observation group 43 cases and control group 43 cases. Control group was given rosuvastatin, the observation group incorporated in the control group on the basis of pioglitazone. The treatment lasted 4 weeks. Comparison of the efficacy of treatment in both groups, before and after treatment NIHSS scores. ADL score, FPG, HbA1c, MT, carotid intimal plaque area changes, and adverse events. Results: The observation total effective rate (90.70%) was higher control group (69.77%) (P<0.05); two groups after treatment NIHSS score decreased, while the ADL score increased (P<0.05); observation group NIHSS score was observed after treatment lower than the control group, and the ADL score was higher (P<0.05); the two groups after treatment FPG and HbA1c decreased (P<0.05); observation group FPG and HbA1c was observed after treatment than the control group (P<0.05); two groups MT and carotid intima plaque area decreased after treatment (P<0.05); observation group MT and carotid intima plaque area treatment than the control group (P<0.05); two groups electrocardiogram, blood, urine routine, liver and kidney functions were normal, and no significant adverse reactions. Conclusion: Pioglitazone treatment of type 2 diabetes in patients with cerebral infarction clinical effect significantly reduces the internal carotid artery intima-media thickness and carotid intima plaque area, is worth studying.