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| β-Estradiol 17-acetate enhances the in vitro vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery | |
| 作者姓名： | Sonia Guzzo Pasquale De Bonis Barbara Pavan Luciano Fadiga |
| 作者单位： | Department of Neuroscience and Rehabilitation |
| 基金项目： | supported by EnTimeMent H2020-FETPROACT-824160(to LF)。 |
| 摘 要： | In the current landscape of endothelial cell isolation for building in vitro models of the blood-brain barrier,our work moves towards reproducing the features of the neurovascular unit to achieve glial compliance through an innovative biomimetic coating technology for brain chronic implants.We hypothesized that the autologous origin of human brain mic rovascular endothelial cells(hBMECs) is the first requirement for the suitable coating to prevent the glial inflammato ry response trigge red by f... |
| 关 键 词： | β-estradiol 17-acetate 17β-estradiol cryopreservation gender-specific gray matter human brain microvascular endothelial cells surgical resections vascular protection white matter |
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