配体偶联脂质体微粒和纳米粒的研究进展

分类综述以共价键和非共价键偶联的各种配体-脂质体微粒和纳米粒的研究进展。配体-脂质体微粒和纳米粒是药物靶向转运的有效载体,可识别并特异性地结合于靶细胞,体内外实验表明其偶联方法,如配体的选择及其在微粒上的分布和结合方式等,将直接影响它们的稳定性、靶向性及配体的免疫活性。

Development of Ligand-coupled Liposome Micro-and Nano-particles as Drug Carriers

The recent development of ligand-coupled liposome micro- and nano-particles by covalent and noncovalent bond was reviewed. These micro- and nano-particles are useful carriers for targeted drug delivery, which can recognize and bind specifically to target cells. Both in vitro and vivo studies have proved that the ligand-liposome coupling approaches, such as the choice of ligands, the distribution on the surface of particles and the binding way, would directly influence their stability and targeting property and the immunoactivity of ligands.