| NOS和BDNF在糖尿病大鼠下丘脑外侧区的表达及其意义 |
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| 引用本文： | 楼航芳,张跃明,张卓文.NOS和BDNF在糖尿病大鼠下丘脑外侧区的表达及其意义[J].浙江中医药大学学报,2007,31(2):160-162. |
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| 作者姓名： | 楼航芳 张跃明 张卓文 |
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| 作者单位： | 浙江中医药大学基础医学院,杭州,310053 |
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| 摘 要： | 目的]探讨NOS和BDNF在糖尿病大鼠下丘脑外侧区的表达及其意义。方法]腹腔内注射链脲佐菌素（STZ）50mg／kg制作糖尿病大鼠模型，于成模后1月末以NADPH—d酶组化法观察糖尿病大鼠下丘脑外侧区（LH）NOS阳性神经元的表达，以免疫组化法观察糖尿病大鼠下丘脑外侧区（LH）BDNF阳性神经元的表达。结果]糖尿病组大鼠下丘脑外侧区NOS及BDNF的表达均较正常组下降，P〈0．01，具有统计学意义。结论]糖尿病大鼠下丘脑外侧区神经元呈退行性变化，这种变化跟糖尿病脑病的发生有着密切的相关。
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| 关 键 词： | 糖尿病 一氧化氮合酶 神经营养因子 脑神经元 下丘脑 |
| 文章编号： | 1005-5509（2007）02-0160-03 |
| 修稿时间： | 2006-12-26 |
Expression and Meaning of NOS and BDNF in the Lateral Zone of Rats' Hypothalamus with Diabetes |
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| Lou Hangfang,Zhang Yueming,Zhang Zhuowen.Expression and Meaning of NOS and BDNF in the Lateral Zone of Rats'''' Hypothalamus with Diabetes[J].Journal of Zhejiang University of Traditional Chinese Medicine,2007,31(2):160-162. |
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| Authors: | Lou Hangfang Zhang Yueming Zhang Zhuowen |
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| Abstract: | Objective] To discuss the expression and meaning of NOS and BDNF in the lateral zone of rats＇ hypothalamus with diabetes. Method] Inject STZ 50mg/kg into the abdomen for rats model of diabetes, after 1 month, observe the positive neuron expression of LH NOS in rats＇ hypothalamus with diabetes with NADPH-d enzyme histo-chemical method, to the positive neuron expression of LH BDNF with NADPH-d immunohisto-chemical method. Result] The expression of NOS and BDNF is both lowered compared with normal group, P〈0.01, with statistical meaning. Conclusion] The neuron in rats＇ lateral hypothalamus with diabetes is degenerating, this change is closely related with brain disease of diabetes. |
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| Keywords: | diabetes nitric oxide synthase nerve nutrition gene brain neuron hypothalamus |
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