| 大鼠局部脑缺血后NADPH-d神经元的变化 |
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| 引用本文： | 史树贵,邵淑琴,陈康宁.大鼠局部脑缺血后NADPH-d神经元的变化[J].第三军医大学学报,2000,22(2):119-122. |
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| 作者姓名： | 史树贵 邵淑琴 陈康宁 |
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| 作者单位： | 第三军医大学附属西南医院神经内科,重庆,400038 |
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| 基金项目： | 国家自然科学基金!(39670269) |
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| 摘 要： | 目的：观察缺血性脑损害中一氧化氮合酶（ＮＯＳ）神经元的变化规律,探讨一氧化氮（ＮＯ）参与缺血性脑损害的机制。方法：采用组织化学染色方法观察大鼠局灶性脑缺血后尼克酰胺腺啶呤二核酸磷黄递酶（ＮＡＤＰＨ－ｄ）阳性神经元的变化规律。结果：大鼠局灶性脑缺血后ＮＡＤＰＨ－ｄ阳性神经元明显增加,缺血２ｈ后出现形态学改变,且以细胞皱缩、胞浆致密为主要死亡方式。结论：ＮＡＤＰＨ－ｄ阳性元对缺血性损害相对耐受,细胞凋
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| 关 键 词： | 脑缺血 NADPH黄递酶 大鼠 NO NOS |
| 修稿时间： | 1999-05-25 |
Changes of NADPHd neurons after focal cerebral ischemia in rats |
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| SHI Shu-gui,SHAO Shu-qin,CHEN Kang-ning.Changes of NADPHd neurons after focal cerebral ischemia in rats[J].Acta Academiae Medicinae Militaris Tertiae,2000,22(2):119-122. |
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| Authors: | SHI Shu-gui SHAO Shu-qin CHEN Kang-ning |
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| Institution: | SHI Shu-gui, SHAO Shu-qin, CHEN
Kang-nin
(Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing
400038) |
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| Abstract: | Objective: To investigate the changes of NOS positive neurons following focal cerebral ischemia. Methods: Focal cerebral ischemia was induced in adult Wistar rats with occlusion of right middle cerebral artery. NADPH diaphorase histochemistry was used to observe the changes of NOS positive neurons. Results: After ischemia, the number of NOS positive neurons in the foci was significantly increased and the neurons began to present morphological changes in 2 h after the ischemia. Conclusion: NOS positive cells are relatively tolerate to ischemic damage and apoptosis is the major manner of their death. |
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| Keywords: | cerebral ischemia NO rat |
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