Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities |
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Authors: | Dongmo Alain B Miyamoto Tomofumi Yoshikawa Kazuko Arihara Shigenobu Lacaille-Dubois Marie-Aleth |
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Institution: | Faculté de Pharmacie, Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB, UPRES-EA 3660, Université de Bourgogne, Dijon, France. |
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Abstract: | Two new flavonoids quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside (1) and apigenin 6-C-2'-O-(E)-feruloyl- beta-D-glucopyranosyl]-8-C-beta-glucopyranoside (2), along with the known isorhamnetin 3-O-alpha-L-rhamnopyranoside (3), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10(-4) g/mL and 5-14% inhibition at 10(-4) g/mL, respectively. |
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