180例生殖异常患者染色体核型分析 |
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引用本文: | 杨晓,王春枝,朱丽娜,何玺玉,马宁,王蔚,刘欣,封志纯. 180例生殖异常患者染色体核型分析[J]. 中国优生与遗传杂志, 2009, 17(4): 51-52 |
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作者姓名: | 杨晓 王春枝 朱丽娜 何玺玉 马宁 王蔚 刘欣 封志纯 |
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作者单位: | 北京军区总医院附属八一儿童医院临床遗传学中心,北京,100700 |
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摘 要: | 目的探讨生殖异常与染色体异常的关系。方法检测180例生殖异常患者外周血淋巴细胞染色体核型。结果180例有不孕不育、畸形、死胎、习惯性流产患者染色体检查出异常核型13例,其中4例克氏综合征(K linefelter综合征),3例平衡易位,3例罗伯逊易位,2例臂间倒位,1例大Y染色体。结论染色体异常是导致不孕不育及自发流产的重要原因之一,对生殖异常患者进行染色体检查可为临床诊断和优生优育提供依据。
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关 键 词: | 染色体 染色体异常核型 生殖异常 |
180 samples analysis of chromosome from reproduction abnormality patients |
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Affiliation: | YANG Xiao , WANG Chun - zhi, ZHU Li - ha, et al. (Clinecal Genetic Center, 81 Children Hospital, Beijing Military General Hospital PLA, 100700) |
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Abstract: | Objective: To investigate the relationship between reproductive abnormalities and chromosome abnormalities . Methods: 180 reproduction abnormality patients'were performed by peripheral blood lymphocytes cultivating to make chromosome G- banding. results: 13 of 180 cases of patients (7.2%) were abnormal chromosome karyotypes. Among 4 case are Klinefeher'syndromes, 3 case are chromosome balanced translocations, 3 case are chromosome Robertson translocations, 2 cases are inversion chromosome, 1 case are polymorphism of Y - chromosome. Conclusion : Chromosome abnormalities are the important factors resulting in female/male infertilities, we advocate that should try to do chromosome investigation for reproduction abnormality oatients. |
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Keywords: | Chromosome Chromosome abnormality karyotype Reproductive abnormalities |
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